Iris Publishers Journal of Dentistry & Oral Health

  Authored by  Adel Bouguezzi, Introduction Careful examination of the mouth may reveal findings indicative of an underlying systemic condition and permit for early diagnosis and treatment. Etiology of acquired hyper pigmentation are many. In some patients it gives a clue to the diagnosis of systemic disorders. Addison’s disease could be a rare endocrine disease during which there’s destruction of the endocrine gland with resultant inadequate secretion of the adrenal cortical hormonescortisol, aldosterone and androgens. Cortisol, the most hormone affected is very important within the body’s ability to deal with stressful situation like infection, hypotension, and surgical procedures [1]. Primary adrenal insufficiency is a life-threatening disorder particularly in stressful situation, since cortisol secretion cannot be increased on demand at all. The prevalence of primary adrenal insufficiency (Addison’s disease) has been reported to be 39 to 60 per million population [2]. Obse...