Iris Publishers - Online Journal of Dentistry & Oral Health| A Study of Prognostic Significance of Perineural Invasion in Oral Squamous Cell Carcinoma
Authored by Zubair Durrani, Introduction Cancer of the oral cavity is a widely prevalent disease and has been listed as the sixth most common cancer worldwide [1]. Squamous cell carcinoma (SCC) accounts for about 90% of all these cases [2]. Despite tremendous research over the last 70 years, the overall prognosis remains at 50% with no gender difference [3]. The incidence, however, is higher in men than women according to WHO data. Prognostic factors include tumor stage, grade, depth of invasion and lymph node involvement. One of the factors which has a prognostic significance but less well studied is perineural invasion (PNI). The aim of this study was to measure the frequency of PNI in our set of oral squamous cell carcinoma patients. Various variables including age, gender, site, size, grade of the tumor was correlated with PNI for their impact upon its incidence. The presence of PNI, size of the nerve involved and tumor focality were then studied for its relation with n...