Iris Publishers - Online Journal of Dentistry & Oral Health| Therapeutic Window of Photodynamic Treatment (PDT) in Conservative Periodontal Therapy -Analysis of Cell Migration Within A Three Dimensional Collagen Matrix-
Authored by Grimm WD, Introduction It was previously found that photodynamic therapy (PDT) enhances anti-bacterial effect of conservative periodontal treatment (for overview see [1]). PDT can be defined as eradication of target cells by reactive oxygen species (ROS) produced by means of a photosensitizing compound and light of an appropriate wavelength. Although PDT is more widely known for its application to the treatment of neoplasms, there is also interest in antimicrobial PDT, as a large number of microorganisms (including oral species) have been reported to be killed in vitro by this approach [2]. PDT has been shown to be effective at killing the periodontopathic organisms responsible for infections in animal models and in clinical-controlled studies [3-5] Sgolastra et al., (2012). Furthermore, from these studies it appears that PDT using energy doses from 1.5 J/cm2 to 5 J/cm2 are capable of eliciting biostimulatory effects in vitro for adherent cells that may be usefu...